A rare condition characterized by excessive thirst and the passing of large quantities of dilute urine. It usually results from a failure of the pituitary gland to secrete ADH (antidiuretic hormone). Diseases of the pituitary gland can cause failure of ADH secretion. The condition may temporarily follow brain surgery. Treatment uses a nasal spray containing ADH. A rare form of the disease, nephrogenic diabetes insipidus, is due to the kidneys not responding to ADH; treatment is by a low-sodium diet and, paradoxically, thiazides (see diuretic drugs).
Diabetes insipidus |
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